Establishment of Cyclodextrin-based Hyperbranched Nanoparticles for Delivering Alpha Mangostin in Cancer Treatment

フォーマット:

学位論文

責任表示:

ドアン　ティ, ホン　ヴァン

言語:

英語

著者名:

ドアン　ティ, ホン　ヴァン  

バージョン:

ETD

概要:

Alpha mangostin (MGS) is a natural xanthonoid compound isolated from a tropical fruit named Mangosteen. It is highly expected as a candidate of anticancer drugs. However, its highly hydrophobic and small molecule limit on applying clinical use. To use MGS in practice, it is needed to develop a suitable drug delivery system. Cyclodextrins (CDs) are biocompatible molecules approved by FDA as the material that can be injected into the human body and have already been … used for a long time. The main advantage of CD comes from its hydrophilic exterior and hydrophobic interior of cavity. Thus, CD can encapsulate hydrophobic compounds like MGS to from complex, then that complex can stay in aqueous solution. The aim of thesis is to establish CD-based nanoparticles (CDNPs) for purpose of delivering MGS effectively in cancer treatment. CDNPs were prepared by use of polyaddition reaction with epichlorohydrin. Particle properties of CDNPs were controlled by changing weight ratio of the composition in reaction. Our CDNPs have a great loading ratio of MGS in comparison with native CDs. Additionally, CDNPs containing MGS has anticancer effect on both in vitro and in vivo experiment. 続きを見る

URL:

http://id.nii.ac.jp/1077/00000709/